A series of case studies highlighting Taxonomy's Value to Society
Implementing the Global Taxonomy Initiative of the CBD
Authentication of Chinese plants helps deliver safe medicine
Relevant sector: Complementary medicine; human health; plant toxicology; phytochemistry; Chinese herbal medicine; trade; botanical nomenclature.
Geographic location: United Kingdom.
Problem statement: In 1999 two cases of kidney failure resulted from the use of a Chinese herb called Aristolochia manshuriensis (Chinese name: Guan Mu Tong) prescribed by practitioners of Chinese herbal medicine.
Methods: Botanists identified the contents of two herbal prescriptions (comprising a variety of loose dried plants) using gross morphological characters (i.e. characters visible to the naked eye). Key to the successful scientific naming of these plants was comparison with reference plant material, which included herbarium specimens whose identity had been confirmed by plant taxonomists. Once one of the ingredients, Aristolochia manshuriensis had been identified in both prescriptions, the Aristolochia material underwent chemical chromatographic analysis to check for the presence of renal toxins called aristolochic acids. These were found in both prescriptions. The patients involved underwent thorough toxicological investigation to eliminate all other possible causes of renal failure.
Outcomes and impacts: Recognising the potential severity
of adverse reactions to this plant species, the then Medicines Control
Agency (MCA) of the UK Department of Health passed new legislation in
2001 banning the manufacture, import, sale or supply of any unlicensed
medicine in the UK which contained herbs in the Aristolochia
and Mu Tong group. The RBG Kew undertook further research to
improve detection methods for aristolochic acids, especially in unlicensed
multi-ingredient patent herbal remedies.
References: 1: http://www.rbgkew.org.uk/scihort/ecbot-cmpac.html; 2: Lord, et. al. 1999. Nephropathy caused by Chinese herbs in the UK. The Lancet, vol. 354, August 7: 1999, pp. 481-482; 3: Kite, G.C. et al. (2002). Detecting aristolochic acids in herbal remedies by liquid chromatograpghy/serial mass spectrometry. Rapid Communications in Mass Spectrometry, 16(6):585-590; 4. The Medicines (Aristolochia and Mu Tong etc.) (Prohibition) Order 2001 SI 1841.
Contact information: Christine Leon/Monique
Simmonds, Chinese Medicinal Plants Authentication Centre (CMPAC), Royal
Botanic Gardens, Kew, Richmond, Surrey, TW9 3AB. Tel: +44 (0)208 332
5702; Fax: +44 (0)208 332 5768; email: email@example.com or firstname.lastname@example.org